Comparative study of the biological behaviour in hamster of two isolates of Leishmania characterized respectively as L. major-like and L. donovani.
نویسندگان
چکیده
H a m s t e r i n o c u l a t e d i n t r a p e r i t o n e a l l y w i t h 1 x 10 7 p a r a s i t e s o f L . d o n o v a n i a n d L . m a j o r l i k e o f th e N e w W o r l d wer e s t u d i e d i n g r o u p s o f 15 , 30 , 6 0 a n d 9 0 d a y s of i n fec t ion . T h e p a r a s i t e l o a d a n d d e n s i t y s h o w e d p r o g r e s s i v e i n c r e a s e w i t h th e e v o l u t i o n o f th e i n fec t i o n a n d w a s h i g h e r i n th e L . d o n o v a n i g r o u p s t h a n i n th e L . m a j o r l i k e g r o u p s . T h e L . m a j o r l i k e g r o u p s s h o w e d p a r a s i t e d e n s i t y h i g h e r i n the s p l e e n t h a n i n th e l i ve r a n d w a s s i m i l a r i n b o t h o r g a n s i n L . d o n o v a n i g r o u p s . T h e h i s t o p a t h o l o g y s h o w e d a d i f fus e m a r k e d h y p e r p l a s i a a n d h y p e r t r o p h y o f th e r e t i c u l o e n d o t h e l i a l s y s t e m w i t h h i g h p a r a s i t i s m i n th e L . d o n o v a n i g r o u p s wh i l e there w as foca l i n v o l v e m e n t o f thes e o r g a n s i n L . m a j o r l i k e g r o u p s , f o r m i ng n o d u l e s of m a c r o p h a g e s t ha t wer e s c a n t l y p a r a s i t i s e d . T h e b i o l o g i c a l b e h a v i o u r c o u l d b e use fu l in th e p r e l i m i n a r y s t u d i e s o f L e i s h m a n ia s t r a i n i n r e g i o n a l l a b o r a t o r i e s a n d u n d e r s t a n d i n g th e h i s t o p a t h o l o g y o f l es i on s c a u sed b y d i f feren t l e i s h m a n i a s p e c i e s .
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ورودعنوان ژورنال:
- Revista do Instituto de Medicina Tropical de Sao Paulo
دوره 30 1 شماره
صفحات -
تاریخ انتشار 1988